Starting with the defensive unit, the one change which should be made is Kieran Gibbs coming in for Nacho Monreal who seems to be in need of a mental break, especially after the joy Raheem Sterling had against him last Sunday.
There have also been calls for Rob Holding to come in for Gabriel but I think we have to give the Brazilian’s partnership with Laurent Koscielny one last try, bearing in mind that Holding is inexperienced as well.
In midfield, Granit Xhaka and Francis Coquelin can continue together but Wenger should not hesitate to bring in Mohamed Elneny if there’s an issue at some point.
Even though this will be another tough Premier League fixture, rotating the squad a bit would be very useful, considering how the defeats at Goodison Park and the Etihad were partially down to some extent of fatigue for key players.
That is why the likes of Alexis Sanchez and Mesut Ozil in particular, have to be given a breather at some point and that time might just be now.
With that being said, the contribution of Olivier Giroud is likely to be needed anyway against a physical and deep-sitting Tony Pulis team.