The Gunners are now set for a tricky trip to Old Trafford where they have not had a great record in recent years.
Unai Emery’s men have been in brilliant form in recent weeks, having put together a 19-game unbeaten run across all competitions.
Arsenal are back in the top four of the Premier League after defeating Tottenham 4-2 over the weekend.
Players like Alex Iwobi and Henrikh Mkhitaryan are expected to be dropped from the starting eleven after being withdrawn at halftime on Sunday.
Emery has not spoken clearly about the fitness of Mesut Ozil but he did admit that there was a chance of the German midfielder being deemed fit for the trip to Old Trafford.
With Granit Xhaka suspended, the Arsenal boss will be forced to make a few changes to his midfield anyway and this could be a great opportunity for Ozil to return while Matteo Guendouzi takes up a defensive role alongside Lucas Torreira.